Is it possible to cure Parkinson or Alzheimer diseases? Turn a patient’s own skin cells into functioning nerve cells? Insert healthy genes to reprogram the cells of a damaged brain? Thanks to her ERC project iN-BraiN, Malin Parmar is studying these types of issues. Her work involves reprogramming adult skin cells directly into dopaminergic cells and inserting genes into the brain to perform such reprogramming on the spot, to repair and substitute damaged cells.
Jojo is living A Cell’s Life: he’s an epidermal cell whose dream has always been to become a neuron. Until his first day of work, he was unaware of the fundamental dogma of biology: once a skin cell, always a skin cell. Jojo is frustrated by the boring routine of his skin cell work until his life will changes: an epidemic has struck the dopamine service. A diehard scientist, Fanny, decides to find out a way to replace dopaminergic cells with skin cells. What will be the destiny of Jojo and his family? Will he be welcomed in the dopaminergic system? And what will be the fate of his human “host”, diagnosed with the beginning of Parkinson’s disease?
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